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alpha-fetoprotein or AFP is a protein produced by the liver of a developing fetus this test is used to assess if the unborn baby has a birth defect or a genetic disease like Down syndrome having a high AFP does not necessarily mean that your baby could be suffering from a birth defect it would also mean that your baby produces more AFP than normal or you could be having twins as two babies would produce more AFP and one conditions like diabetes mellitus and your weight would also affect the results the AFP test is recommended to all pregnant women in the first trimester of pregnancy the test may also be recommended to a female who is above 35 years of age has a family history of birth defects or has diabetes mellitus do remember that if your FB results are high it does not necessarily mean that the unborn baby would be suffering from a birth defect it only means that the doctor has to run further tests in order to make a diagnosis he may ask for another AFP test followed by an ultrasou