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so we know for patients with metastatic melanoma about 50 percent of patients will have long-term benefit to blockade of anti-ctla-4 and anti-pd1 with epilimab and volumab so thereamp;#39;s been a number of ongoing efforts looking at other immune activation pathways so targeting cebp beta the rationale is that cbp beta is prognostic itamp;#39;s widely expressed in a number of different cancers and this pathway leads to proliferation survival and inhibition of apoptosis and so this allows cancer cells to continue to grow and develop
