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I recognize all the faces here some more than others and just to briefly say that my background is there for 10 years I chaired the appraisals committee for nice which was and I still bear the scars by the way and my presentation therefore is very much of a personal presentation but also have a nice centric but that doesnt mean to say that just apply a pan-european if not internationally as you will have come to appreciate the first question I posed and Ill return to this right at the end is the is there a reg and HTA regulatory divide were not different people we have different perspectives and whether that perspective causes a divide or whether it should be parallel and competent development together so on the regulatory perspective as youre aware of course efficacy and safety and on the HTA perspective and political effectiveness and cost-effectiveness very bland statements but it is obvious to all of you that the same evidence not infrequently if not actually very frequently l
