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this is a quick guide to help you determine your alzheimeramp;#39;s risk with your apoe alleles we often get questions on how to determine the risk of alzheimeramp;#39;s disease the apoe gene has been extremely well researched for alzheimeramp;#39;s however you should keep in mind that your genes are only one part of this equation alzheimeramp;#39;s is influenced by both your genes and environmental factors so knowing your genetic risk should encourage you to understand the importance of doing what you can do to prevent alzheimeramp;#39;s disease so as a note before we get started do not use your ancestry dna for this data there is a known error in the apoe data for certain years so now what is your risk the apoe has three common forms the e2 is the least common and is actually associated with a decreased risk of alzheimeramp;#39;s the e4 is a little more common but it will increase your risk of getting the disease and the e3 is the most common but it does not increase or decreas