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okay so thanks back so hi everyone and some of you may have had a bit of news last night in The Herald Sun and itamp;#39;s getting to hit the media now so this is incredibly exciting so Iamp;#39;m going to talk today about a new drug screen platform for MND so and this is acute amending foundation initiatives and I just like to point out this is the worldamp;#39;s first combination of technologies and right here in Melbourne so so I think letamp;#39;s start with what is the problem within India at the moment why is the medicine cabinet not full why are there limited options and I think of MND is a very challenging disease and itamp;#39;s largely due to three core problems so for those of you familiar with the disease this disease is never the same in two individuals this disease has a very different clinical pattern and this is quite a useful diagram from a recent review paper from Paul tormund and colleagues in which thatamp;#39;s shown that MMD has bulbar onset has arm on settl