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mitochondrial diseases cover a wide range of conditions caused by genetic mutations in the UK alone they affect thousands mitochondria are the powerhouses of the cell they use a process called oxidative phosphor relation to generate energy but a mitochondrian is a complex piece of machiner and a lot can go wrong it takes around 1,500 proteins for mitochondria to function and problems with many of these can lead to disease the cellamp;#39;s nuclear DNA creates all but 13 of these proteins the rest are coded for by the DNA in the mitochondria themselves and mutations in either can cause problems a cell has just one nucleus and many mitochondria all the cells mitochondria contain their own DNA if a mutation affects mitochondrial DNA some might be healthy others defective and different cells can have different numbers of defective mitochondria inside them that means that some cells may be less affected than others the diseases caused by damag mitochondria can also be varied they can affec
