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thank you welcome everyone Dr Mandel here tinnitus is a major epidemic worldwide over 50 million people have some type of tinnitus many of these are much worse than others itamp;#39;s that ringing humming hissing static Cricket screeching whooshing roaring pulsing those sounds can drive you crazy I have something that I like to share with the world itamp;#39;s a neural transmitter thatamp;#39;s not working correctly from the inside of the ear to the brain your tinnitus can be a problem from glutinate glutamate controls the communication between the auditory centers in the brain and the inner hair cells of the cochlea when these hair cells become damaged by things like exposure to loud noise or ototoxic substances excessive glutamate is released too much glutamate opens neuronal sodium channels and stops them from closing causing the neurons to keep firing this continuation of firing allows free radicals and inflammation continuing to accrue to get worse affecting the mitocho