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- Hi, Iamp;#39;m John Cleveland from the University of Glasgow. Well, I think the big highlight of course, are the guidelines and the guidelines have given us the foundational four as theyamp;#39;re being talked about. So we have the RAS inhibitors the ACE and ARNis, the beta blockers, the MRAS and now the SGLT2 inhibitors. And so, and thatamp;#39;s solid. Whatamp;#39;s interesting is how the picture is evolving for HFmrEF and what Iamp;#39;m calling HFnEF we have a new phenotype also called HFsnEF which is becoming very interesting. So HFpEF now encompasses everything from basically 40% right to the top. But now into these three segments it seems to be genetically different. These are patients with an injection fraction above 70%. They seem to have a bad prognosis. There may be hypertrophic cardiomyopathy and other diseases in there. And it looks already as though we might have a new treatment for them, which are cardiac myocin inhibitors. So, so being developed for hypertrophic