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okay its after three so I think well start this final PhD completion similar of Marek Mary come is unique in that I think hes got the most supervisors any student Ive ever seen and in fact whats interesting is about half of them are actually here so Mariks interesting in that hes tried to apply bioinformatics to clinical cancer evolution problems and he realized them quite early on in his PhD that one of the issues that no ones looking at structural variants for the evolution of cancer Sam Eriks developed a method which is going to go through in some detail today about how hes used structural variants to call evolution in cancer thanks to the introduction Chris I would just like to begin by acknowledging the traditional owners of the land on which we meet today Orangery people of the Kulin nation and i pay my respects to elders past present and future so the prevailing theory of cancer evolution is that cancer begins with a single progenitor cell that has acquired mutations