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thank you and I wanted to thank Angela and Dominic for uh the kind introduction and invitation so um Iamp;#39;m going to talk about a soft share based uh label labeling method um that is uh um in 25 years in the in the work and and obviously 13c guided metabolomics is something new to offer to uh basic science and animal research as well as clinical science and I Iamp;#39;d like to cover a few critical areas just to to to make you understand a little bit um better about what the Tracer means and uh what the purpose of it practically itamp;#39;s to as as Dominic was mentioning it it to monitor the fate of specific substrates and Iamp;#39;m emphasizing specific because we are looking for um uh targeted information in the metabolic Network and relate that to biology and more importantly find relevant enzyme reactions u in in very complicated metabolic networks to uh address a number of things one is what disease markers and disease disease states are that we can determine usin