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entresto a new medication for people with heart failure what is intresto when your heart muscle becomes weak your kidneys make hormones that narrow your blood vessels and cause your body to hold on to salt and water while helpful at the start over time this puts strain on your heart and causes it to become bigger and weaker your heart protects itself by making other helpful hormones that relieves some of the stress and strain these hormones relax your blood vessels and causes your body to get rid of extra salt and water intresto contains two medications the first medication blocks harmful hormones that narrow your blood vessels and make you retain water the second medication supports helpful hormones causing effects like blood vessel relaxation to last longer intresto is a tablet taken by mouth twice a day you will start with a low dose which increases over a few weeks your health care provider will watch your blood pressure blood potassium level and kidney function while adjusting you