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my name is john gallin and im the director of the clinical center and a co-organizer of this course so the topic that im going to cover is an overview of the history of this business which is after all risky business for the patients as well as big business for the pharmaceutical industry and the biotechnology industry but we can learn a lot from going back to the beginning and seeing some of the things that happen so i will try to give you a survey sort of a hobby of mine and i enjoy it and i want to just say right out front at the beginning that its impossible to cover everything and to recognize everyone and if i omitted your favorite historical feature you can tell me and next time ill try to include it but i apologize but theres literally thousands and thousands of superstars that make this a wonderful story so let me start with the definition of clinical research and this is not a historical definition but it sets a perspective for the course this was produced at nih in 1996