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In this video tutorial, Veronica from Michigan Medical School's Office of Research explains the key details of cooperative agreement funding mechanisms, specifically NIH U-type grants. She emphasizes the significant role played by funding agency staff and outlines best practices for applying. Unlike standard grant mechanisms such as NIH R-type grants, cooperative agreements involve more active participation from funding agency staff in both scientific and administrative aspects. The primary goal of cooperative agreements is to support and stimulate investigator-driven research. Veronica highlights the importance of understanding these differences before deciding to apply for a cooperative agreement award.