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Motor neuron disease is not one but a group of rare neurological conditions in which motor neurons - the nerve cells that control skeletal muscle movement are progressively degenerated. Loss of motor neurons results in muscle weakness that gradually worsens over time, impairing the bodys ability to move, eat, speak, or even breathe. Usually, motor instructions from the brain are transmitted to the muscles via 2 neurons: an upper motor neuron starts in the primary motor cortex of the cerebrum; and a lower motor neuron continues from the brainstem or spinal cord, forming the corticobulbar and corticospinal tracts, respectively. The corticobulbar tracts control muscles of the face, head, and neck and are responsible for facial expression, speech, swallowing, among others. The corticospinal tracts control muscles of the torso and limbs. Lesions of upper and lower motor neurons affect the muscles in different ways. A loss of upper motor neuron function ofte
