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Because we have requirements than some other funders do not, here are some tips that should help you prepare a winning LOI. Number one: Read the PFA. PFA is short for PCORI funding announcement. This is your starting point. Successful applicants have thoroughly reviewed the PFAs and ensure that their research idea aligns with what the specific program is looking for. About half of LOIs are rejected for non-responsiveness to the PFA. So, be sure to review this document closely and dont try to force a topic into an opportunity that is not a right fit. Also, be sure to look at the project duration and budget sections. Each PFA has different requirements -- some allow five year studies and others only three, some five million in direct costs and others 1.5 million. Be sure you can conduct your research within whatever constraints apply. Number two: Participate in town-halls. During the LOI and full application periods, we host a number of applicant town-halls. Participating in a town-hall