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Dr. Grande's video tutorial focuses on performing the sign test using SPSS. He demonstrates this method using fictitious data, specifically a variable named "score" generated from a Depression Inventory with 40 records. Additionally, a median variable is set to 50. The sign test is introduced as a nonparametric alternative to the one-sample t-test, which typically compares scores to a population mean. In this context, Dr. Grande highlights the suitability of the sign test given the data's configuration. The video aims to guide viewers through the process of conducting the sign test in SPSS while encouraging likes and subscriptions for further content.