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In America, the blood industry is a multibillion-dollar market valued at $3.3 billion in 2021, with blood contributing over 2% of U.S. exports. Due to a lack of substitutes for human blood, demand often exceeds supply, leading to critical shortages that can have life-or-death implications. The industry faces challenges, particularly regarding blood donation policies for specific groups, such as gay men, as the FDA considers a study that could lift the longstanding ban. Major companies in blood collection, including Grifols, CSL Plasma, Takeda's BioLife, and Octapharma, play significant roles, with donors often compensated; the collected plasma is used for therapeutic purposes by large pharmaceutical firms.