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This webcast discusses the results of the Paradigm HF clinical trial, which focused on a new approach to treating heart failure with reduced ejection fraction known as Angiotensin Receptor Neprilysin Inhibitor, abbreviated as ARNI. The trial results were published in the New England Journal of Medicine. The webcast is co-sponsored by the European Society of Cardiology and the New England Journal of Medicine. The moderator is Mariell Jessup from the University of Pennsylvania, joined by distinguished international experts including Professor John McMurray and Dr. Milton Packer, the co-principal investigators of the Paradigm HF trial.