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[Music] [Music] hello everyone and welcome to todays webinar on conducting sample size reassessment with time to event endpoints I would now like to introduce Pantelis Bois whose principal strategic consultant at site L thank you Lisa and once again thank you everybody for attending this webinar this is the next to last in our series of East orientation webinars and today were going to be covering time to event as endpoints and how to conduct study with a sample size reassessment so let me go into the presentation mode so the format is going to be pretty much the same as in the previous webinars where Im going to be covering a little bit of the methodology of sample size reassessment with an emphasis for time threes and end points then were going to begin into a case study where were going to see how going to be able to run such a design within the rel southeast and were going to break for questions and a conclusion so once again this is the fourth out of series of five webinars