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The video tutorial discusses how to search for assignments and changes in ownership for issued patents and published applications using various criteria like patent number, publication number, signer, or assignee name. It demonstrates searching the USPTO assignment database for a specific patent, which displays a list of assignments associated with that patent number. Users can explore further by searching for the current assignee, revealing multiple assignments transferred from the original assignor on specific dates. The tutorial highlights the option to download and view the patent or associated publication, as well as the ability to export assignment results into Excel for future reference.