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In this video tutorial by Carla on clinical physio, she discusses essential questions to ask during a subjective examination focused on past medical history, drug history, and social history. The key acronym introduced is "hashtag thread Sox," which represents various medical conditions and histories to consider. Each letter signifies a specific aspect: H for fractures, T for thyroid conditions, H for heart conditions, R for rheumatoid conditions, I for epilepsy, A for asthma and breathing issues, D for diabetes, S for previous steroid use, O for osteoporosis, C for personal or family history of cancer, and S for history of surgery. Carla encourages viewers to remember this acronym for effective patient assessment.