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my names wayne schreffler im the chief of pediatric allergy at massachusetts general hospital and its my pleasure to talk to you this morning about sort of the second uh phase of treatment options those that are in earlier clinical stage or or here are my disclosures so i i would like to take this time um to provide context for the speakers to follow and hopefully without any redundancy weve heard a lot of great talks already in the first day about food allergy pathogenesis i want to talk a little bit about you know sort of perhaps an emerging paradigm around that that i hope will be provocative and that i think might inform how we can think about um both the natural history and ultimately treatment response and hopefully can lead to improvements in rational design of therapy and then ill briefly review a few examples of early stage therapy some of which i think have a next generation potential or or or fit into you know sort of this schema of our understanding pathogen so the en