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Wayne Schreffler, Chief of Pediatric Allergy at Massachusetts General Hospital, discusses early clinical-stage treatment options for food allergies. He aims to provide context for upcoming speakers while avoiding redundancy from previous talks. Schreffler introduces an emerging paradigm in understanding food allergy pathogenesis, which he hopes will provoke thought and enhance insights into natural history and treatment responses. He emphasizes the potential for improvements in therapy design and briefly reviews several early-stage treatments that exhibit next-generation potential within this expanding framework.