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In the emergency department at 2 A.M., a 26-year-old man is admitted after a severe car accident, suffering from internal bleeding. A code Omega is activated to signal the need for immediate and massive blood transfusions. The blood lab responds rapidly, dispatching blood packages, as timing is crucial for the patient's survival. Doctors Siobhan and Mark explore the blood donation process by donating their own blood. First, they complete a screening questionnaire to determine eligibility, focusing on health, medications, and travel history. Next, their hemoglobin levels are checked to ensure they have enough red blood cells for donation, utilizing a small blood sample for testing.