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testosterone production the hypothalamus releases gonadotropin-releasing hormone or gnrh in pulses every 60 to 90 minutes to stimulate the pulsatile release of luteinizing hormone lh from the pituitary gland into the bloodstream lh binds the lh receptor on the latex cells of the testes binding initiates a cascade of events which include the conversion of cholesterol depicted as ldl here to pregnenolone followed by a series of reactions which convert pregnant alone to testosterone testosterone secreted by the testes diffuses into the peripheral circulation to be carried to target tissues in liver muscle and adipose tissue testosterone binds directly to its androgen receptor or ar to exert its biological effect in skin hair the prostate gland and gonadal tissue testosterone must be converted to dihydrotestosterone or dht by 5-alpha reductase in order to bind the androgen receptor in bone and brain testosterone is converted by aromatization to estradiol or e2 which binds the estrogen rece
