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and i have composed another list of discussion points throughout the day and iamp;#39;m just going to share them for day two as we did for day one uh and you should be able to see them hopefully terry you see them and these are based on the different uh um uh the different sessions uh um in this symposium so the first part was about the experimental systems for exploring mutation on signatures uh and uh we thought some interesting things that came of the impact on dna damage and dna repair on the signatures can we look beyond mutational signatures how do we understand tumor progression agents i mean we can sequence permutation of signatures but what do we do for tpas to better understand them we also need to be very aware of the limitations of the individual systems wild type mice do not have apple back i mean ruben shows some beautiful work where he has masks with apple back should we be using other individual model systems other than mice and same ques
