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the first slide there are my disclosures on what i intend to talk about tonight just briefly is of course how we test with these entrap fusions and and iamp;#39;ll talk a little bit generally about we test for for any single genomic drive and then concentrate specifically on end track fusions and then finish with the esmo guidelines which have been recently published on and track testing next slide please emily now just a little bit of um repetition thereamp;#39;s never any harm in that i know the colors already covered these but uh these three genes the neurotrophic propamycin receptor kinase genes they are normally involved with neuronal development in kinetics and there are three of them one two three on chromosomes one nine fifteen encoding three proteins track abc and whenever you get three genes like that on different chromosomes it means theyamp;#39;re pretty important um and itamp;#39;s quite unusual uh in this sort of context uh the problem from our point of view tonight i