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Clodagh: Weamp;#39;ve discovered, actually, how the cell deals and defends against DNA viruses, as well as damage to our own genome, and it detects them with the same sensor, but it triggers a completely different switch. Govind: Two universal threats to all organisms are DNA viruses and DNA breaks. We have found that proteins that handle DNA breaks also handle the response and restriction of viral DNA. Weamp;#39;ve shown, for the first time, that these DNA repair proteins sense virus DNA and eliminate their replicative potential. DNA repair proteins serve as security guards inside the nucleus. They catch virus DNA and escort them out of the zone. If a cell experiences a huge amount of DNA damage, then these security guards will be pulled away from the viral DNA and allow the viral DNA to replicate to high levels. Clodagh: We discovered that if you actually have DNA damage in your own genome and the alarm goes off, actually that recruits in all of the forces, all the police, National
