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whenever there is an injury or a challenge to an organ or tissue a whole process of renewal takes place in the body to help restore optimal health soon after the injury the affected tissue releases specific compounds that travel through the blood to the bone marrow when the compounds released by the injured tissue docHub the bone marrow these messengers tell the stem cells in the bone marrow to divide and create new stem cells which are then released from the bone marrow into the bloodstream slowly the number of stem cells increases in the blood circulation at the same time the affected tissue releases another compound called stromal-derived factor 1 or sdf-1 that attracts stem cells as stem cells circulate in the fine blood vessels of the affected tissue and sense the presence of this compound they stop in the blood flow and migrate into the tissue inside the tissue stem cells slowly migrate to the very site of injury where sdf1 is being secreted when they docHub the site of the