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Major injury can cause extensive trauma to the muscle including toxins such as a snake bite. Even after extensive damage small groups of healthy cells can be found. These cells, including muscle stem cells, engage in the regeneration process. Satellite cells activate and generate daughter myoblasts that begin the process of rebuilding the destroyed muscle fibres. Residual debris is removed by the macrophages. New muscle fibres are generated by the differentiation and fusion of hundreds of myoblasts within the collagen matrix of the basement membranes. During this regeneration process, satellite cells will self-renew. They are then set aside for future repair events.
