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When testing autoinjectors, alignment and fixture design have a direct impact on the variability of cap removal force data. Instrons Autoinjector testing fixtures are designed to simplify alignment, minimize side loading during cap removal and support a range of established device geometries while offering the flexibility to easily accommodate customized or nonstandard devices. The cap removal fixture consists of a base and insert aligned with the systemamp;#39;s grips and crosshead to ensure a loading occurs along the test axis. The base can be equipped with a series of interchangeable cap removal inserts that fit a range of commercially available autoinjector devices. Each insert has been carefully designed to ensure proper engagement of the cap for removal without imparting unnecessary side loads that influence maximum force data. Secured by three thumbscrews, the cap removal inserts can be easily swapped out to accommodate new devices. The simple design makes it easy to machine n