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who uses drugs just about everybody use of psychoactive substances is incredibly common with over 90 of people in the united states taking at least one on a regular basis while many people are able to use psychoactive substances without negative effects on their health a docHub minority of people will develop problems as a result of substance use people can experience problems related to substances in three ways intoxication withdrawal and addiction these three things are closely related but theyamp;#39;re ultimately separate conditions so itamp;#39;s important to get them straight from the get-go intoxication is an acute state of being under the influence of a psychoactive substance with the specific mix of signs and symptoms associated with each substance being known as its toxodrome withdrawal is also an acute state but this time it involves the physiological and psychological effects of suddenly stopping a substance which are often the opposite of what you would see in a sta