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Aug 6th, 2022
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How to Revise result in AFP

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What does it mean if my AFP PLUS test result is screen positive? A positive AFP PLUS test means that you are in a higher likelihood group for having a baby with a neural tube defect or a chromosome abnormality. However, it does not prove by itself that there is anything wrong with the pregnancy.
A positive test with a high AFP suggests a birth defect like spina bifida. Thats typically a result of 2.5 times or more than the average level of AFP youd expect to see at that point in your pregnancy. A positive test with low AFP could mean a problem like Down syndrome or Edwards syndrome.
High AFP levels may also mean that you are having more than one baby. You may also get a false-positive result. That means that your AFP results arent normal, but your baby is healthy. If your AFP test results arent normal, you will likely have more tests to help make a diagnosis.
AFP by Presence or Absence of Neural Tube Defect. The specificity is 0.97, indicating that there are 3% false-positives.
Iron reduction therapy docHubly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL ( for each).
An AFP level between 0 ng/mL to 40 ng/mL is normal for adults. An extremely high level of AFP in your bloodgreater than 400 ng/mLcould be a sign of liver tumors. High levels of AFP may mean other cancers, including Hodgkin disease, lymphoma, and renal cell carcinoma (kidney cancer).
AFP tests are good tools for detecting genetic disorders or neural tube defects. Up to 9 in 10 fetuses with neural tube defects were diagnosed because the AFP test detected abnormalities. But AFP tests arent perfect. In every 1,000 pregnant people who get the AFP test, up to 50 get abnormal results.
There are approximately 25 to 50 abnormal test AFP results for every 1,000 pregnancies tested. Of these abnormal results, only 1 in 16 to 1 in 33 will actually have a baby that has been affected by a neural tube defect or other condition.
Normal and Critical Findings Maternal AFP levels in pregnancy start to rise from about the 14th week of gestation up until about 32 weeks of gestation. Between 15 and 20 weeks, AFP levels usually range between 10 ng/ml to 150 ng/ml.
Measuring the alpha-fetoprotein (AFP) level by a blood test checks for open NTDs. About 80 percent of the time when a woman is carrying a child with spina bifida or anencephaly, her blood test will show a higher than normal AFP level.

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