Revise motif in 600

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How to revise motif in 600

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How does V600E affect BRAF?

The BRAF protein is part of a communication route, or signaling pathway, in cells that is necessary for their growth and survival. In many cancer types, the V600E mutation in the BRAF gene causes the protein to be overly active, leading to uncontrolled cell growth and driving the development of cancer.

What is a motif in a folktale?

Motif-Index of Folk-Literature; a Classification of Narrative Elements in Folk-Tales, Ballads, Myths, Fables, Mediaeval Romances, Exempla, Fabliaux, Jest-Books, and Local Legends (Stith Thompson, 1932) Used by folklorists to identify the elements or building blocks which make up a tale.

What are the most common folklore motifs?

It includes in-depth examination of such motifs as: Bewitching; Chance and Fate; Choice of Roads; Death or Departure of the Gods; the Double; Ghosts and Other Revenants; the Hero Cycle; Journey to the Otherworld; Magic Invulnerability; Soothsayer; Transformation; Tricksters.

What is the BRAF mutation in melanoma V600E?

One of the most common types is the BRAF V600E mutation. The name V600E describes the nature and location of the mutation: V and E represent the amino acids (building blocks of protein) that mutated. In this case, valine (V) got replaced by glutamic acid (E).

What is the BRAF mutation mechanism?

BRAF is one of the most frequently mutated oncogenes recognised in melanoma. The most frequent oncogenic BRAF mutations consist of a single point mutation at codon 600 (mostly V600E) that leads to constitutive activation of the BRAF/MEK/ERK (MAPK) signalling pathway.

What is the BRAF V600E point mutation?

The BRAFV600E mutation is also common in more histologically aggressive cancers, and has been reported in 80% to 83% of tall-cell variant PTC,2830 10% to 15% of poorly differentiated carcinomas, and 20% to 30% of anaplastic carcinomas. BRAFV600E has only rarely been reported in follicular thyroid cancers.

How does V600E mechanistically alter BRAF function?

This result supports the hypothesis that the V600E mutation mimics the activation loop phosphorylation in wild-type B-Raf. One mechanism where the Val-to-Glu mutation could induce an active conformation in B-Raf is through destabilizing the hydrophobic pocket occupied by Val600 in wild-type B-Raf.

What is a motif in genetics?

Motif is a region (a subsequence) of protein. or DNA sequence that has a specific. structure. Motifs are candidates for functionally. important sites.

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