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- Why do you gain weight with antidepressants and mood stabilizers? Thats what Im talking about today. Im Dr. Tracey Marks, a psychiatrist and I make a mental health education videos. Todays topic is based on several viewer questions for me to talk about this. The short answer is we dont know the full mechanism. But here are two proposed ways that antidepressants and antipsychotic medications that we use for mood stabilization cause weight gain. I will also talk about what we do about it. The way these drugs cause weight gain is by blocking histamine 1 receptors. We usually think of histamine as something that is associated with allergies and your immune response. If youre exposed to something your body is sensitive to, you get a histamine response that can look like itching, runny nose or even shortness of breath. And then you can take an antihistamine like Benadryl, it slows down that allergic reaction to make you feel better. Thats how it works though from the neck down. Hist
