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remission from depression is defined about 10 years ago we did a study in which we asked patients over 500 patients who were an ongoing treatment what did they consider to be important in defining remission from the depression and not surprisingly we found that resolution of symptoms which has been the typical way symptom remission has been defined in the literature was not considered to be the most important factor in determining remission rather patients indicated that improvement in functioning feeling back to their normal self ability to cope with stress were more important than symptom resolution determining whether or not they were in from remission we did a second study in which we had patients indicate yes or no did they consider themselves to be in remission and then rate their level of depression psychosocial functioning and quality of life and we found that all three of those variables were associated with self-reported patient remission and they were independently associat