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hello and welcome to the shiki science show where in this video were going to talk about a recent nature publication that has come up from the david sinclair lab whereby they show that neurons in the eyes of mice can be reprogrammed to a more youthful state in which they reacquire the ability to regenerate and restore fission so in this video well take a look at this data and discuss how cellular reprogramming may be able to refer different hallmarks of aging by refirsting or reprogramming in this case epigenetic marks and so well go into some detail about these three programming factors and discuss potential mechanisms as to how they might be acting in a cell to be able to mediate this reversal of epigenetic marks so i first learnt about this study when i read david sinclairs book lifespan which is where we shall begin with this video and so if you havent read his book or watched my amazing summary video on it then you first need to understand that david explains the aging proce