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In response to a YouTube inquiry, the speaker addresses a viewer's question related to the gold standard in the context of COVID-19. The viewer expresses uncertainty about the validity of relying on a gold standard, suggesting that despite its absence, sufficient data could be gathered to determine the normal variation of the disease. The speaker notes that the viewer's question, while not entirely clear, hints at the possibility of understanding disease variation through accumulated data. This discussion emphasizes the importance of data collection in forming a baseline for comparison, even in the absence of an established gold standard.