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In this video, the speaker discusses the importance of letters of recommendation and provides guidance on how to obtain them. It's suggested to secure 4 to 5 letters, with at least two from science professors, which is considered essential. Additionally, one letter should come from a non-science professor, while others can be from a research PI, a physician you shadowed, or a community/volunteer activity. The speaker emphasizes the importance of getting recommendations from individuals who know you well, highlighting the need to build relationships with these letter writers, particularly with those like your research PI.