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The main message highlights the progress in delivering ultra-cold chain vaccines, even in remote areas, but emphasizes the enormous resources required for that effort. There's a need for a variety of vaccines with different characteristics. Recent press releases have announced efficacy data on vaccines that can be stored at -20°C or refrigerated temperatures, which could facilitate distribution and use. The next crucial step is to evaluate this data more thoroughly, as press releases only provide limited information. A comprehensive review of the data is necessary, including addressing any questions that may arise during the evaluation process.