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feminizing hormone therapy feminizing hormone therapy is an option that can help people who are transgender fulfilled theyre affirmed feminine gender identity and feel more comfortable in their bodies but like other medical treatments there are benefits and risks what is feminizing hormone therapy feminizing hormone therapy changes the levels of sex hormones in the body sex hormones are the chemical messengers in the body that regulate the development of sex characteristics such as hair growth fat distribution and muscle mass the most common medicines used are estrogen and spironolactone what you take varies greatly from person to person deciding what to take depends on your health because each hormone therapy has different benefits and risks what are the benefits and risks feminizing hormone therapy can help a persons body more closely match their gender identity physical changes to the body include softening of the skin less muscle mass beginning breast development and decreased d