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Welcome to another MedCram COVID-19 update. Were going to talk about this new medication, Molnupiravir, which is an oral antiviral medication for the treatment of mild to moderate COVID-19 in at-risk adults. Lets look at the mechanism of how this medication works and see how effective it is at doing what its supposed to do. On the left here we have Molnupiravir, which gets metabolized to this thing on the right, which is an analog of a nucleotide. Were going to talk more about why thats important and how that fits into how this medication prevents the replication of the virus. So here were going to review how the SARS-CoV-2 virus infects the cell and replicates, and as you can see here on the left side of the screen, the SARS-CoV-2 viral particle infects the cell through the ACE-2 receptor and releases its messenger RNA. This messenger RNA then goes on to replicate itself, as we will review right now. As you can see here, the viral particle as its a
