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how does the body replace blood during a whole blood donation we aim to take just under a pint about four seven zero MLS of blood which works out at no more than 13% of your blood volume after donation your body has an amazing capacity to replace all the cells and fluids that have been lost take bread sells millions of them are being made and dying every second when you give what you lose red cells and the body needs to make more to replace them special cells in the kidneys called peri tubular cells since that the level of oxygen in the blood has decreased due to the loss of red cells and start secreting a protein called erythropoietin this passes through the bloodstream until it docHubes the bone marrow the soft fatty tissue inside the bone cavities the bone marrow produces stem cells the building blocks that the body uses to make the different blood cells red cells white cells and platelets the erythropoietin sends a message to the stem cells telling more of them to develop into red
