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In this video tutorial, the presenter explains the process for making changes to a purchase order in SAP. To start, they navigate to the main screen and enter the transaction code ME22N. Once in the purchase order display view, the user clicks on the option for "Other Purchase Order Number," enters the specific purchase order number, and then clicks the spectacles and pen icon to open the order in editable mode. The presenter emphasizes that after saving, changes cannot be made to the vendor, payment terms, or major components; however, modifications to price, delivery rate, conditions, and some text are permitted.