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Dr. Scharfstein discusses the current state of COVID-19, highlighting a decline in cases and hospitalizations. He notes the ongoing requirement for mask-wearing in public spaces. The focus is on the potential change in public policy as deaths decrease, suggesting that regional variations will impact policy shifts. He anticipates a change in the national mood as fatalities decline further, indicating that COVID-19 may fade into the background in 2022. However, he acknowledges the possibility of unforeseen events that could disrupt this trend. Overall, he expresses optimism that life will be less disrupted in the upcoming year.