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In this video tutorial, we demonstrate how to remove all punctuation from a text string using Python's regular expressions. We examine a sample text containing various punctuation marks such as at symbols, parentheses, brackets, question marks, and colons. The goal is to strip these characters during text pre-processing to focus solely on the words. To achieve this, we utilize the `re.sub` function from the regular expression package, implementing a pattern that matches punctuation. Essentially, we substitute any punctuation with an empty string, effectively cleaning the text for further analysis.