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At 2 A.M., a 26-year-old man arrives at the emergency department after a severe car accident with critical injuries and internal bleeding. A Code Omega is activated, prompting the blood lab to initiate a massive transfusion protocol, rapidly sending blood to the emergency department, where timely availability can be crucial for survival. Doctors Siobhan and Mark introduce the process of blood donation, beginning with the screening questionnaire to determine donor eligibility, which assesses health, medications, and travel history. They also check hemoglobin levels to ensure the donor has adequate red blood cells to contribute.