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[Music] hello everyone my name is Johan and this is the tutorial on removing unwanted variation from high dimensional data and being helped out today ROM yours here and Saturday and Anna and Marie so all of us are running the tutorial today the the general format is going to be for the for the first session the first hour and a half Im gonna go through some slides and do some demonstrations of the ruv package and then during the second half of the session thats going to be a lot more hands-on and that will mostly be run by Romney arm reset the day and Anna and and those will work through again youll work through a bunch of example data sets okay um so for this for this first bit for the first session Im gonna Im gonna go through some slides and also introduce a shiny app and the basic structure is gonna be for roughly the first half hour so Im gonna give just some I wont go so far as to say theoretical but some some general conceptual view of removing unwanted variation and the