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treponation of the skull is one of the oldest surgical procedures in history its also a form of brain surgery the oldest medical or scientific writing on the surgery dates from the hippocratic corpus a collection of ancient greek medical works dating as far back as the 5th century bc brain or more accurately skull surgery was not uncommon in the ancient world and can be found the world over from china to peru one burial site in france which dates back to 6500 bc shows prehistoric trepidation hole drilling but before complex hand tools this was done with flint or even seashell involving scraping a hole this method could take up to an hour but these surgeries did save lives and it was popular particularly with the romans romans drove holes in peoples heads with specialized tools known as trebes cetera the tools and the wounds were washed with wine having some antiseptic properties not always but the romans often covered these holes with nailed down metal plates for the romans this surg