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♪♪♪ - The current standard of care for the treatment of depression is based on what we call the monoamine deficiency hypothesis. Essentially presuming that one of three neurotransmitters in the brain is deficient or underactive. - Neurotransmitters can be thought of as the chemical messengers within the brain. Its what helps one cell in the brain communicate with another to pass that message along. - But the reality is there are more than a hundred neurotransmitters in the brain and billions of connections between neurons. So we know that thats a limited hypothesis. - For decades, we thought that the primary pathology, the primary cause of depression was some abnormality in these neuro-transmitters, specifically serotonin or norepinephrine. - However, norepinephrine and serotonin did not seem to be able to account for the symptoms of depression in people who had major depression. Instead, the chemical messengers between the nerve cells in the higher centers of the brain involved
