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maze end is the first and only pill with evidence in Progressive multiple sclerosis and it has the potential advantage over gillenia in that you may not need a first dose observation were going to talk about the mechanism of action the unique dosing regimen and of course the results in clinical trials and side effects I have some time stamps if you want to skip ahead and remember what Stephen King said the truth is in the details Maison or saponimod is a simple small molecule pictured here and its similar to the multiple sclerosis drugs gillenia and zyppozia gillenia is the first drug in this class FDA approved in 2010. this drug can easily cross the blood-brain barrier but its primary action is in the peripheral immune system it is a sphingosine one phosphate receptor modulator or s1p phosphate receptor modulator and it prevents lymphocytes a subclass of white blood cells involved in inflammation in Ms from exiting the lymph nodes and getting in to the brain spinal cord and optic ne